Bacteria-phage coevolution drives variation in bacterial wilt disease incidence via resistance-virulence trade-offs - PubMed
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- #bacterial wilt disease
- #resistance-virulence trade-off
- #bacteria-phage coevolution
- Bacteria-phage coevolution leads to local adaptation between Ralstonia pseudosolanacearum and its phages in tomato fields.
- Phage infectivity is highest on sympatric bacteria, and bacteria from healthy plants show greater phage resistance than those from diseased plants.
- Phage-bacteria coevolution results in field-specific mutations in phage receptor genes, which are negatively associated with bacterial virulence.
- Resistance-virulence trade-offs in the pathogen explain why phage-resistant but weakly virulent isolates are linked to healthy tomato plants.
- These coevolutionary dynamics contribute to patchy distribution of bacterial wilt disease across fields.