Downregulation of miR-10b-3p by EBV promotes tumor growth and metastasis via ITGAV in nasopharyngeal carcinoma - PubMed
5 hours ago
- #EBV
- #miR-10b-3p
- #nasopharyngeal carcinoma
- EBV infection downregulates host miR-10b-3p in nasopharyngeal carcinoma (NPC).
- Restoring miR-10b-3p inhibits NPC cell proliferation, migration, invasion, and EMT, while its inhibition promotes these effects.
- miR-10b-3p directly targets ITGAV, reducing its expression and suppressing STAT5 and ERK1/2 signaling.
- Overexpression of miR-10b-3p reduces tumor growth and lung metastasis in mouse models.
- ITGAV expression partially reverses miR-10b-3p's tumor-suppressive effects, highlighting an EBV-regulated miR-10b-3p/ITGAV/STAT5-ERK1/2 axis in NPC pathogenesis.