FBXO6 regulates colon cancer migration and invasion via ITGB1 ubiquitination and downstream signaling - PubMed
7 hours ago
- #FBXO6
- #Colorectal Cancer
- #Ubiquitination
- FBXO6 regulates colon cancer migration and invasion via ITGB1 ubiquitination and downstream signaling.
- Higher FBXO6 expression correlates with better prognosis in CRC patients, though it decreases in advanced-stage tumors.
- FBXO6 overexpression suppresses invasive and migratory abilities of HCT116 and RKO cells, while knockdown promotes these traits.
- ITGB1 identified as a key substrate of FBXO6, with FBXO6 binding to ITGB1 and reducing its stability.
- FBXO6 attenuates downstream FAK/PI3K/AKT/ERK signaling, and ITGB1 overexpression counteracts FBXO6's suppressive effects.
- In vivo models show FBXO6 reduces tumor growth, Ki67 levels, and ITGB1-associated signaling.
- FBXO6 suppresses CRC cell proliferation, migration, and invasion by targeting ITGB1 for ubiquitination.
- FBXO6 has potential as a prognostic biomarker and therapeutic target in CRC.