NLRP3 Inflammasome Activation-Induced Acute Papillitis as a Trigger of Acute Pancreatitis - A Novel Mechanism of Microlithiasis-Induced Acute Pancreatitis - PubMed
6 hours ago
- #NLRP3 inflammasome
- #microlithiasis
- #acute pancreatitis
- NLRP3 inflammasome activation-induced acute papillitis is proposed as a novel mechanism for microlithiasis-induced acute pancreatitis.
- Human papillary biopsies showed higher CD45-positive leukocyte infiltration and NLRP3 expression in microlithiasis-induced acute pancreatitis compared to alcohol-induced cases and controls.
- In vitro studies with bone marrow-derived macrophages showed increased IL-1β secretion and caspase-1 activation when stimulated with cholesterol monohydrate and calcium bilirubinate crystals.
- Mice studies demonstrated microlithiasis formation via a lithogenic high-fat diet and devazepide, with higher LDH, GPT, and ALP levels in serum when combined with caerulein-induced pancreatitis.
- The study concludes that biliary microlithiasis triggers acute papillitis via NLRP3 inflammasome activation in macrophages, without causing pancreatic outflow obstruction.