Lachnospiraceae-Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function - PubMed
14 hours ago
- #barley leaf
- #Lachnospiraceae
- #myocardial infarction
- Barley leaf (BL) supplementation improves cardiac function and reduces adverse remodeling in myocardial infarction (MI) mice.
- BL enhances gut epithelial barrier function and reduces bacterial lipopolysaccharide transfer, linked to cardioprotection.
- BL enriches Lachnospiraceae in the gut microbiota; antibiotic treatment abolishes BL's cardioprotective effects.
- Lachnospiraceae-derived extracellular vesicles (L-EVs) promote intestinal stem cell function via ERα-Slc6a14-Hippo signaling.
- L-EVs show biosafety, stability, and colonic retention, offering potential therapeutic benefits for MI.