Co-expression of IL15 promotes effector differentiation and sustained proliferative capacity in ALPPL2-specific human CAR T cells - PubMed
4 hours ago
- #ALPPL2
- #IL15
- #CAR T cells
- Co-expression of IL15 enhances effector differentiation and sustained proliferative capacity in ALPPL2-specific human CAR T cells.
- CAR T cells with human sequences (ABBz) reduce immune-mediated rejection risks.
- IL15 promotes T-cell survival, improving expansion and persistence of CAR T cells.
- ABBz CAR T cells show specificity, effective cytolytic function, and cytokine production.
- IL15 co-expression in ABBz T cells leads to NK-like effector differentiation and reduced apoptosis.
- ABBz CAR T cells exhibit robust antitumor activity, further enhanced by IL15 co-expression.