Mitochondrial dynamics and their role in the pathogenesis of age-related macular degeneration: A comprehensive review - PubMed
5 hours ago
- #Retinal Health
- #Mitochondrial Dynamics
- #Age-Related Macular Degeneration
- Mitochondrial dysfunction is central to age-related macular degeneration (AMD), particularly affecting the retinal pigment epithelium (RPE).
- Dysregulation of mitochondrial dynamics—fission, fusion, biogenesis, and mitophagy—leads to fragmented and dysfunctional mitochondria in AMD.
- Consequences include bioenergetic deficits, oxidative stress, and inflammation, driving AMD pathology.
- Therapeutic strategies targeting mitochondrial pathways, such as antioxidants and dynamic modulators, show promise for intervention.
- Future advances in biomarkers and personalized approaches may address root causes of AMD.