Regulation of calcium homeostasis by S100A12 drives NETosis in chronic kidney disease - PubMed
5 hours ago
- #NETosis
- #Chronic kidney disease
- #Calcium signaling
- S100A12 regulates calcium homeostasis, driving NETosis in chronic kidney disease (CKD).
- Integrated bioinformatics and machine learning identified S100A12 as a key diagnostic biomarker for CKD.
- S100A12 expression correlates with neutrophil infiltration and elevated NETosis markers in CKD patients.
- In vitro studies show S100A12 promotes NETosis via calcium overload, inhibitable by verapamil.
- Targeting S100A12-mediated calcium signaling could mitigate renal inflammation in CKD.