Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeostasis and membrane integrity in acetaminophen-induced liver injury - PubMed
6 hours ago
- #AILI
- #liver regeneration
- #iron homeostasis
- STEAP4 plays a critical role in liver regeneration after acetaminophen (APAP)-induced liver injury (AILI).
- Liver-specific STEAP4 knockout (L-STEAP4 KO) mice showed delayed liver recovery at 48 hours post-APAP, despite similar initial injury levels.
- Loss of STEAP4 led to endolysosomal iron buildup, lysosomal membrane damage, and impaired mitophagy, reducing hepatocyte proliferation.
- Deferiprone (DFP) restored mitochondrial and lysosomal functions, protecting against AILI.
- Overexpressing STEAP4 or TFEB, or posttreatment with DFP, repaired lysosomal membranes and mitigated AILI.
- Targeting STEAP4-mediated endolysosomal iron overload could offer new therapeutic strategies for AILI.