Integrative Multi-Omics and Single-Cell Profiling Identify Chitinase Domain Containing Protein 1 (CHID1) as a Prognostic Biomarker in Glioblastoma - PubMed
6 hours ago
- #Biomarker
- #Glioblastoma
- #CHID1
- CHID1 identified as a prognostic biomarker in glioblastoma (GBM) through integrative multi-omics and single-cell profiling.
- CHID1 expression is higher in GBM compared to normal brain tissue and associated with poor overall survival.
- Single-cell analysis revealed tumor-associated expression patterns of CHID1 in malignant samples.
- Pathway enrichment analyses linked CHID1 to oxidative phosphorylation, redox-related processes, DNA repair, and cell cycle pathways.
- The study provides a comprehensive characterization of CHID1 in GBM, integrating bulk transcriptomics, single-cell RNA sequencing, and tissue-level validation.
- CHID1 is established as a GBM-associated transcriptional marker linked to metabolic and redox-related programs.