NMN improves high-fat-diet-induced myocardial damage of aging mice through Sirt3/PINK1/Parkin signaling pathway - PubMed
5 hours ago
- #metabolic cardiomyopathy
- #NMN
- #autophagy
- NMN improves high-fat-diet-induced myocardial damage in aging mice via the Sirt3/PINK1/Parkin signaling pathway.
- Long-term high-fat diet (HFD) consumption accelerates cardiac aging and contributes to metabolic cardiomyopathy.
- NMN, a key NAD+ precursor, shows promise in mitigating age-related cardiac decline.
- Study involved 14-month-old male C57BL/6J mice divided into normal-diet (ND), HFD, and HFD+NMN groups.
- NMN treatment significantly reduced heart index, myocardial fibrosis, and expression of senescence and inflammatory markers.
- NMN upregulated anti-inflammatory factor IL-10 and enhanced autophagy-lysosomal function in cardiac tissue.
- In vitro, NMN attenuated palmitic acid-induced cytotoxicity and improved impaired autophagy flux in H9c2 cardiomyocytes.
- Protective effects of NMN were abolished by 3-TYP, a selective Sirt3 inhibitor.
- Findings suggest NMN as a therapeutic candidate for metabolic cardiomyopathy.