NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seedling establishment - PubMed
5 hours ago
- #ABI5
- #proteasome
- #NUCLEOPORIN1
- NUCLEOPORIN1 (NUP1/NUP136) is part of the Nuclear Pore Complex (NPC) and plays a role in Arabidopsis seedling establishment.
- NUP1 is highly expressed in seeds and interacts with ABI5, a key negative regulator of germination.
- Mutations in NUP1 lead to ABA hypersensitivity during seedling establishment, with ABI5 mutations rescuing the NUP1 mutant phenotype.
- NUP1 physically associates with ABI5 and the 26S proteasome, facilitating ABI5 degradation.
- Under ABA stress, NUP1 mutation delays ABI5 degradation by retaining it in the nucleolus.
- The study suggests NUP1 anchors the proteasome to NPC, regulating seedling establishment through proteasome-mediated ABI5 degradation.