A distinct psoriasis-atopic dermatitis overlapping phenotype in adults with dual type 2 and type 3 immune features and favorable response to JAK1 inhibition - PubMed
3 hours ago
- #JAK1 Inhibitor
- #Psoriasis-Atopic Dermatitis Overlap
- #Type 2 and Type 3 Inflammation
- A distinct psoriasis-atopic dermatitis overlapping phenotype in adults is driven by dual type 2 and type 3 immune features.
- Patients present with symptoms including ill-defined erythematous plaques, thin scales, excoriation, and intense itching.
- Immune profiling reveals co-existence of Th2/Tc2 and Th17/Tc17 cells in skin and blood with JAK1-STAT2/6 signaling involvement.
- Prior targeted biologics for psoriasis and atopic dermatitis often showed inadequate responses in these patients.
- JAK1 inhibitors effectively achieved minimal disease activity during a median follow-up of 17 months.
- No progression to classic psoriasis or atopic dermatitis phenotypes was observed in patients treated with JAK1 inhibitors.