Gut microbiome disparities reflect type 2 diabetes progression and medication status - PubMed
5 hours ago
- #metformin
- #microbiome
- #type 2 diabetes
- Type 2 diabetes mellitus (T2D) prevalence is rapidly increasing in India.
- Gut microbial diversity is significantly reduced in clinically diagnosed T2D patients (KT2D), coinciding with antidiabetic drug use, primarily metformin.
- Lactobacillus abundance increases with disease progression.
- Clostridium_sensu_stricto_1 is associated with glucose homeostasis and insulin sensitivity.
- β diversity differs only between controls and prediabetics (PD), with no other pairwise differences.
- T2D progression and oral antidiabetic medications remodel the gut microbiome in this south Asian cohort.
- There is a need to reassess antidiabetic treatment efficacy using larger longitudinal studies.