Echinacoside regulates the IRE1/XBP1 signaling pathway through HSP72 to reduce endoplasmic reticulum stress and improve diabetic kidney disease - PubMed
6 hours ago
- #Endoplasmic reticulum stress
- #Echinacoside
- #Diabetic kidney disease
- Echinacoside (Ech) improves diabetic kidney disease (DKD) by targeting HSP72.
- Ech activates the IRE1/XBP1 pathway to reduce endoplasmic reticulum stress.
- The study used db/db mice and high glucose-induced HK-2 cells as DKD models.
- Kidney proteomic sequencing identified HSP72 as a core regulatory protein.
- SPR, MST, and MD confirmed direct interaction between Ech and HSP72.
- HSP72 knockdown models demonstrated Ech's efficacy is dependent on HSP72.
- Ech improves insulin resistance, glucolipid metabolism, and reduces kidney fibrosis.
- Ech mitigates mitochondrial oxidative stress and apoptosis in kidney cells.
- Findings suggest Ech as a potential therapeutic agent for DKD.