Generation of membrane-permeable cyclic peptides inhibiting protein-protein interaction - PubMed
4 hours ago
- #protein-protein interaction inhibitors
- #cyclic peptides
- #cell permeability
- Small cyclic peptides are promising for targeting difficult protein-protein interactions (PPIs) due to their ability to bind targets and cross cell membranes.
- The research demonstrates that screening diverse cyclic peptide libraries can identify inhibitors of PPIs, exemplified by discovering an inhibitor for Keap1-Nrf2.
- Optimization through design-build-test cycles yields membrane-permeable compounds active in live cells, enabling discovery of cell-permeable PPI inhibitors from scratch.
- Large, structurally diverse cyclic peptide libraries provide a pathway to harness small cyclic peptides for intracellular interactions.
- Funding from Swiss National Science Foundation and EU Framework Programme supports the study.