Prophylactic haemostatic treatment to control iatrogenic bleeding during endobronchial biopsy (PROTECT study): a multicentre, randomised, single-blind, placebo-controlled study - PubMed
2 days ago
- #clinical trial
- #prophylactic haemostasis
- #endobronchial biopsy
- The PROTECT study investigated prophylactic haemostatic treatment for controlling iatrogenic bleeding during endobronchial biopsy.
- 462 participants were randomized into three groups: adrenaline, ice-cold saline, or saline (placebo).
- Prophylactic haemostasis did not statistically improve bleeding severity or visual analogue scale outcomes overall.
- A subgroup of patients aged <65 years showed a trend toward reduced bleeding with ice-cold saline (RR 0.90, p=0.04).
- The study confirmed the safety of prophylactic haemostasis but found no significant overall benefit.
- Further research is needed to explore the potential benefits in younger patients.