TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses - PubMed
5 hours ago
- #livestock resilience
- #gene editing
- #antiviral defense
- TRIM29 knockout pigs show enhanced disease resilience by boosting type I interferon antiviral defenses.
- Gene editing was used to create TRIM29-KO pigs, which exhibited broad-spectrum antiviral activity without adverse health effects.
- TRIM29 functions as a negative regulator of type I IFN signaling, making it a potential antiviral target.
- Knockdown of TRIM29 in PK15 cells increased antiviral immunity against PRV and VSV by enhancing type I IFN production.
- TRIM29-KO mice also demonstrated improved antiviral ability against PRV and VSV infections.
- TRIM29-KO pigs showed elevated type I IFN levels and reduced susceptibility to PRV, VSV, and TGEV infections.