Benzodiazepine exposure during early pregnancy and risk of miscarriage: dose-response, half-life classification, and individual agents - PubMed
4 hours ago
- #Miscarriage Risk
- #Pregnancy
- #Benzodiazepine
- Benzodiazepine exposure during early pregnancy is associated with a modest increase in miscarriage risk (adjusted OR: 1.241).
- Higher doses and longer-acting benzodiazepines showed numerically higher odds ratios, though estimates lacked precision across subgroups.
- Individual agents like brotizolam had a significant association (OR: 1.454), while etizolam and alprazolam did not show significant increases.
- The study used a nested case-control design from a Japanese database (2005-2023), matching 44,118 miscarriage cases with 132,317 controls.