PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery - protocol for an international, multicentre, pr
5 hours ago
- #Cardiac Surgery
- #Personalized Medicine
- #Neurological Outcomes
- The PRECISION study investigates personalized cardiac anesthesia and cerebral autoregulation's impact on neurological outcomes in cardiac surgery patients.
- Primary focus is on postoperative delirium (POD) and stroke, aiming to reduce these complications through individualized blood pressure monitoring.
- The study is an international, multicenter, prospective cohort study involving patients aged 65+ undergoing elective cardiac surgery with cardiopulmonary bypass.
- Real-time monitoring includes near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) to assess cerebral autoregulation (CA) indices.
- Primary endpoint is POD, assessed using 3D-CAM or CAM-ICU, with secondary endpoints including composite neurological outcomes and neurocognitive disorders.
- The study aims to enroll 500 participants to achieve 90% statistical power in evaluating the effect of MAP deviations from CA limits on POD risk.
- Ethical approvals have been obtained, and results will be disseminated through conferences and peer-reviewed publications.