Hepatic metabolic burden and all-cause mortality across glucose metabolism statuses in a cardiovascular-kidney-metabolic syndrome population: insights from the National Health and Nutrition Examinatio
6 hours ago
- #CKM Syndrome
- #Hepatic Metabolic Burden
- #All-Cause Mortality
- The study investigates the link between hepatic metabolic burden, measured by Fatty Liver Index (FLI), and all-cause mortality in cardiovascular-kidney-metabolic (CKM) syndrome populations across different glucose metabolism statuses.
- No significant independent association was found between FLI and mortality in individuals with normoglycemia or prediabetes after multivariable adjustments.
- Among individuals with diabetes, higher FLI was significantly associated with increased mortality risk, showing a J-shaped nonlinear dose-response relationship.
- Joint analyses indicated that elevated FLI combined with impaired glucose metabolism progressively increased death risk, highest in those with diabetes and FLI ≥60.
- The findings highlight that the relationship between FLI and mortality in CKM populations varies by glycemic status, emphasizing the need to consider glucose metabolism context.