Association between endothelial activation and stress index and mortality in critically ill patients with atrial fibrillation: In MIMIC database: A Retrospective Cohort Study - PubMed
5 days ago
- #Mortality Risk
- #Atrial Fibrillation
- #Endothelial Activation
- The study investigates the association between the Endothelial Activation and Stress Index (EASIX) and mortality risk in critically ill patients with atrial fibrillation (AF).
- Data from the MIMIC-IV database was analyzed, including 3,193 patients with AF.
- Elevated EASIX levels were significantly associated with higher in-hospital and ICU mortality rates.
- Adjusted analyses showed HRs of 1.09 for in-hospital mortality and 1.10 for ICU mortality per unit increase in EASIX.
- Subgroup analyses indicated interactions between EASIX and conditions like sepsis and respiratory failure.
- Sensitivity analysis confirmed the robustness of the findings, with the highest EASIX group showing the greatest mortality risk (HR 2.08 for in-hospital death).
- The study concludes that EASIX is a potential tool for identifying high-risk AF patients, though further research is needed to validate its broader applicability.