Relationship between the microbiome and obesity-associated cancer risk using Mendelian randomisation - PubMed
2 days ago
- #microbiome
- #obesity
- #cancer risk
- Study investigates the causal relationship between the gut microbiome and obesity-associated cancer risk using Mendelian randomisation.
- Genetically predicted BMI was linked to increased risk of colorectal, kidney, endometrial, lung, and oesophageal cancers.
- Seven microbial taxa were associated with colorectal cancer (CRC) risk, with Actinobacteria showing the strongest effects.
- Actinobacteria mediated 29% and 21% of the BMI to CRC risk, collectively accounting for 50% of the relationship.
- No consistent microbiome mediation was found for other cancers besides CRC.
- Findings support microbiome-targeted interventions to reduce CRC risk in obese individuals.