Dual association patterns between microglial activation and neuronal health in Alzheimer's disease: a whole-brain MRSI/PET study - PubMed
5 days ago
- #Alzheimer's disease
- #Neuroinflammation
- #Microglial activation
- Microglial activation in Alzheimer's disease (AD) can either support or damage neuronal function.
- Study involved 40 healthy controls, 37 mild cognitive impairment (MCI) patients, and 62 AD patients using whole-brain MRSI and PET imaging.
- Higher microglial activation and lower N-acetylaspartate (NAA) levels were found in MCI and AD patients, correlating with cognitive decline.
- Positive correlation between microglial activation and NAA/Aβ in early amyloid-accumulating regions in controls and MCI.
- Negative correlation between microglial activation and NAA in hippocampus (MCI) and temporal/occipital regions (AD).
- First identification of dual spatial association patterns between microglial activation and neuronal health in AD.