Proteoglycan Mimetics-Based Antimicrobial and Anti-Inflammatory Microneedles Restoring Dysregulated Lipid Metabolism and Suppressing Skin Atrophy for Acne Treatment - PubMed
2 days ago
- #acne treatment
- #lipid metabolism
- #microneedles
- Proteoglycan-mimetic comb polymer (HMC)-based dissolving microneedles (HMC-PEP MNs) are developed for acne treatment.
- HMC-PEP MNs target acne pathophysiology: bacterial colonization, lipid dysregulation, chronic inflammation, and impaired tissue repair.
- The microneedles enable sustained release of antimicrobial and anti-inflammatory peptides via non-covalent interactions.
- HMC-PEP MNs effectively eradicate Cutibacterium acnes infection and suppress pro-inflammatory mediator expression.
- They regulate cholesterol and linoleic acid metabolism and inhibit the IGF1/IGF1R/PI3K/AKT/mTOR signaling pathway.
- HMC-PEP MNs promote collagen synthesis and prevent post-acne dermal atrophy.
- The study presents a promising therapeutic strategy with potential for clinical translation.