Effect of Steroids on Anti-nephrin Autoantibodies and B cells in Minimal Change Disease - PubMed
6 hours ago
- #anti-nephrin antibodies
- #steroids
- #minimal change disease
- Autoantibodies against nephrin play a pathogenic role in minimal change disease (MCD).
- 70.6% of therapy-naïve MCD patients had anti-nephrin antibodies at diagnosis.
- All anti-nephrin positive patients achieved complete remission after 8 weeks of steroid treatment.
- 40% of anti-nephrin negative patients did not reach clinical remission.
- Anti-nephrin positive patients had a higher fraction of plasmablasts at diagnosis.
- Steroid treatment led to significant changes in B-cell subpopulations in anti-nephrin positive patients.
- Plasmablasts, naïve B cells, and transitional B cells decreased, while marginal zone-like B cells increased post-treatment.