Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices - PubMed
17 hours ago
- #Autoimmunity
- #Type 1 Diabetes
- #ImmTAAI
- Researchers developed a bispecific immune agonist called ImmTAAI, which binds to beta cells and suppresses autoreactive T cells.
- ImmTAAI molecules target preproinsulin peptide-HLA-A2 complexes on human beta cells in live pancreas slices.
- The treatment increases T cell motility and inhibits effector molecule and cytokine secretion, protecting beta cells from T cell killing.
- ImmTAAI also enhances motility of islet-infiltrating T cells in slices from a recent-onset type 1 diabetes donor and preserves insulin secretion.
- This approach demonstrates potential for localized immunoregulation in type 1 diabetes, offering a targeted therapeutic platform for autoimmune diseases.