Systemic Integrative Mechanisms and Intervention Strategies in Exercise-Induced Skeletal Muscle Damage: Evidence from Animal, Clinical, and Multi-Omics Studies - PubMed
5 hours ago
- #multi-omics
- #exercise-induced muscle damage
- #ferroptosis
- Exercise-induced muscle damage (EIMD) is not just mechanical but a systems-level failure of stress integration.
- Key factors include disturbances in Ca2+ homeostasis, metabolic stress, redox imbalance, and immune activation.
- Maladaptive remodeling can lead to mitochondrial dysfunction, ferroptosis, chronic inflammation, and impaired regeneration.
- Reactive oxygen species, iron-dependent lipid peroxidation, and immune polarization are critical molecular tipping points.
- Satellite cells integrate metabolic history and epigenetic memory, linking repetitive injury to sarcopenia and metabolic disease risk.
- Multi-omics, digital monitoring, and individualized rehabilitation may enable precision management of EIMD.