L-Se-methylselenocysteine alleviates iron deposit-induced anxiety- and depression-like behaviors in chronic renal failure rats receiving iron therapy via Nrf2/GPX4 activation - PubMed
6 hours ago
- #Chronic Renal Failure
- #Iron Overload
- #Nrf2/GPX4 Pathway
- L-Se-methylselenocysteine (L-SeMC) alleviates iron deposit-induced anxiety and depression-like behaviors in chronic renal failure (CRF) rats.
- Iron supplements in end-stage renal disease (ESRD) patients may lead to cerebral iron overload, linked to neuropsychiatric symptoms.
- Human study shows ESRD patients have higher depression scores and increased iron deposition in the brain compared to healthy controls.
- Animal study demonstrates L-SeMC reduces iron deposition, improves renal function, and restores neuronal health in CRF rats.
- L-SeMC activates the Nrf2/GPX4 pathway, reducing ferroptosis and alleviating anxiety- and depression-like behaviors in CRF rats.