Photon-Counting Computed Tomography for Tissue Characterization in Patients With a Left Ventricular Hypertrophic Phenotype - PubMed
21 hours ago
- #Photon-counting CT
- #Left ventricular hypertrophy
- #Tissue characterization
- Photon-Counting CT (PCCT) characterizes left ventricular hypertrophy (LVH) with accuracy comparable to cardiac magnetic resonance (CMR).
- PCCT differentiated etiologies: transthyretin cardiac amyloidosis showed highest mass and ECV, hypertrophic cardiomyopathy intermediate ECV with patchy fibrosis, and secondary LVH minimal enhancement.
- PCCT strongly correlated with CMR for LV mass index, ejection fraction, ECV, and late enhancement extent (r-values 0.868-0.998).
- PCCT detected CMR late gadolinium enhancement with excellent accuracy (AUC 0.994, sensitivity 99%, specificity 100%).
- PCCT enables coronary angiography and is viable when CMR is contraindicated, impractical, or nondiagnostic.