CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation - PubMed
6 hours ago
- #phosphorylation
- #spindle assembly
- #mitosis
- CDK1-dependent phosphorylation of NuMA's N-terminal region, primarily at serine 203, drives assembly of the dynein-dynactin-NuMA (DDN) complex.
- This phosphorylation acts as a mitotic phospho-switch, ensuring stable multivalent interactions necessary for accurate chromosome segregation.
- NuMA-N phosphorylation, along with its dynein-binding site and Spindly-like motif, is required for functional spindle assembly during mitosis.