The glymphatic system as a brain scavenger in Alzheimer's disease: mechanisms and therapeutic implications - PubMed
5 hours ago
- #Alzheimer's disease
- #Neuroinflammation
- #Glymphatic system
- The glymphatic system acts as a brain scavenger, clearing waste like amyloid-β (Aβ) and tau proteins.
- Glymphatic dysfunction in Alzheimer's disease (AD) leads to toxic protein accumulation, driving disease progression.
- Astrocytes and microglia play key roles in regulating glymphatic function via AQP4 channels and phagocytosis.
- Loss of AQP4 polarization, fluid exchange obstruction, and microglial dysregulation worsen AD pathology.
- Diagnostic advances (Aβ/tau PET imaging, CSF biomarkers) enable early AD detection.
- Therapeutic strategies targeting glymphatic-astrocyte-microglia interactions (AQP4 enhancers, TREM2 agonists) show promise.