Crocin Mitigates Glutamate Excitotoxicity and Tau Hyperphosphorylation by Modulating EAAT2 and Akt/Tau Pathway in a Scopolamine-induced Rat Model of Alzheimer's Disease - PubMed
4 hours ago
- #Excitotoxicity
- #Crocin
- #Alzheimer’s disease
- Crocin (Cr) mitigates glutamate excitotoxicity and tau hyperphosphorylation in a scopolamine-induced rat model of Alzheimer's disease.
- Scopolamine administration increased glutamate, NMDAR, and p-tau levels while reducing p-Akt, GABA, and EAAT2 levels, leading to hippocampal neurodegeneration.
- Crocin treatment restored neurotransmitter balance, downregulated NMDAR, upregulated EAAT2, increased p-Akt expression, and reduced tau phosphorylation.
- Histological analysis confirmed structural recovery of hippocampal neurons after crocin treatment.
- The study involved 48 adult male rats divided into six groups, including control, crocin, scopolamine, and combinations with memantine.