Cellular Prion Protein Engages the N-Methyl-d-Aspartate Receptor through N- and C-Terminal Domains - PubMed
5 hours ago
- #NMDA Receptor
- #Prion Protein
- #Neurobiology
- Cellular prion protein (PrPC) regulates neurite outgrowth, cell survival, myelin maintenance, and immunity.
- PrPC interacts with the N-methyl-d-aspartate receptor (NMDA-R), triggering cell-signaling responses.
- Two binding sites in PrPC for NMDA-R were identified: one in the N-terminal disordered region and another in the C-terminal structured region.
- PrPC binds to both GluN1-GluN2B complexes and GluN1 in isolation.
- N-linked glycans in PrPC inhibit binding to GluN1, and additional glycosylation further reduces this binding.
- PrPC can interact with NMDA-R when membrane-anchored, released in extracellular vesicles, or shed from the cell surface.