Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in Non-Small Cell Lung Cancer - PubMed
5 hours ago
- #LKB1
- #NSCLC
- #tumor suppressor
- LKB1 is a serine/threonine kinase that acts as a key tumor suppressor in Non-Small Cell Lung Cancer (NSCLC).
- Mutations or loss of LKB1 function occur in 20-30% of NSCLC cases, impairing energy sensing and promoting metabolic reprogramming.
- LKB1 deficiency leads to disrupted cell polarity, increased invasion and metastasis, and resistance to therapies like radiotherapy and immune checkpoint inhibitors.
- Targeting LKB1 signaling pathways offers potential for novel therapeutic strategies in treating NSCLC patients.