Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma - PubMed
3 months ago
- #Autophagy
- #Ferroptosis
- #Multiple Myeloma
- SDE2 overexpression is linked to poor prognosis in multiple myeloma (MM).
- SDE2 binds to ATG5, promoting its ubiquitination and degradation, which suppresses autophagy and ferroptosis.
- Knockdown of SDE2 restores ATG5 levels, reactivating autophagy and sensitizing MM cells to ferroptosis.
- Combined SDE2 silencing and ATG5/7 activation (Antitumor agent-82) synergistically inhibits tumor growth in vitro and in vivo.
- Targeting the SDE2-ATG5 axis presents a novel therapeutic strategy for MM by promoting autophagy-dependent ferroptosis.