Blood-brain barrier breakdown in traumatic brain injury: current insights and future directions - PubMed

5 hours ago

Traumatic brain injury (TBI) involves primary and secondary injury cascades, with the blood-brain barrier (BBB) playing a critical role in maintaining brain microenvironment.
BBB breakdown after TBI leads to acute and long-term consequences, including microcirculatory insufficiency, neurotoxin accumulation, cerebral edema, axonal damage, neuronal cell death, and neuroinflammation.
Key signaling molecules like Tie-2, EphB3, and Cav-1 are involved in post-injury pathophysiological processes, and regulating the BBB holds therapeutic potential for TBI.

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