Large-scale plasma proteomics for predicting future cardiovascular and all-cause mortality among individuals with cardiovascular-kidney-metabolic syndrome stage 0-3 - PubMed
5 hours ago
- #Proteomics
- #CKM Syndrome
- #Mortality Prediction
- Study analyzed 39,007 UK Biobank participants with CKM syndrome stages 0-3 to assess plasma proteins' predictive value for cardiovascular and all-cause mortality.
- 56 proteins significantly linked to cardiovascular mortality and 269 to all-cause mortality; 7-8 key proteins improved predictive models (C-statistics increased).
- Elevated protein levels observed over a decade before death, with increasing trajectories, enhancing risk stratification and long-term mortality prediction.