Targeted Ferroptosis Improves RPE Phagocytosis via MERTK/NFE2L2/HMOX1 Axis to Alleviate Retinitis Pigmentosa - PubMed
5 hours ago
- #Retinitis Pigmentosa
- #RPE Phagocytosis
- #Ferroptosis
- Retinitis pigmentosa (RP) is an inherited retinal disorder causing progressive rod and cone degeneration and RPE dysfunction leading to vision loss.
- The study uses RCS rat models and human primary RPE cells to investigate RP, employing scRNA-seq to analyze transcriptional differences and ferroptosis-related signals.
- Ferroptosis inhibitor Fer-1 showed therapeutic efficacy, improving RPE phagocytic function and reducing cytoskeletal disorganization in RP models.
- NFE2L2 and HMOX1 were significantly upregulated in RCS rats and MERTK-deficient RP models, indicating their role in ferroptosis.
- Targeting the MERTK/NFE2L2/HMOX1 axis to inhibit ferroptosis presents a potential therapeutic strategy for MERTK-deficient RP.