Fibroblast-Derived Microfibrillar-Associated Protein 5 Exerts Cardioprotective Effects After Myocardial Infarction by Activating the NOTCH2 Signaling in Cardiomyocytes - PubMed
5 hours ago
- #Myocardial Infarction
- #MFAP5
- #NOTCH2
- MFAP5, derived from cardiac fibroblasts, increases during myocardial infarction (MI) and has cardioprotective effects.
- MFAP5-knockout mice showed worsened cardiac dysfunction post-MI, while overexpression improved outcomes.
- MFAP5 interacts with NOTCH2 receptors on cardiomyocytes, activating NOTCH2 signaling to reduce apoptosis.
- The study highlights MFAP5's role in inhibiting cardiomyocyte apoptosis via NOTCH2 pathway activation.