Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia - PubMed
6 hours ago
- #single-cell transcriptomics
- #hair follicle miniaturization
- #androgenetic alopecia
- Single-cell transcriptomics identifies early changes in cell subpopulations and altered hair follicle (HF) stem cell fate in male androgenetic alopecia (AGA).
- Hypercontractility of the connective tissue sheath (CTS) activates PIEZO1, leading to ectopic apoptosis of HF progenitor cells and suppressed matrix/ORS cell proliferation.
- Mechanotransduction via CTS contraction depletes progenitor pools and impairs HF growth, driving progressive miniaturization.
- Pharmacological inhibition of CTS contraction with ML-7 improves HF growth in ex vivo models and humanized mice.
- The study highlights the peri-follicular CTS as a promising therapeutic target for AGA intervention.