Safety and efficacy of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson's disease: a prospective, multicentre, single-arm
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- #bilateral treatment
- #Parkinson's disease
- #MRgFUS
- Bilateral MRgFUS pallidothalamic tractotomy showed significant improvement in motor scores for Parkinson's disease patients with motor complications.
- Unilateral treatment demonstrated safety and efficacy, but bilateral treatment increased persistent moderate or severe adverse events, especially affecting speech, gait, and balance.
- The study was a prospective, multicentre, single-arm trial involving 54 patients receiving unilateral treatment and 40 proceeding to bilateral treatment.
- Median motor scores improved by 32% at 3 months post-bilateral treatment, with benefits lasting up to 12 months.
- Rigorous patient selection and counselling on cumulative risks are recommended for bilateral procedures due to increased adverse events.