Microenvironmental Regulation of Central Nervous System Myelination and Remyelination - PubMed
4 hours ago
- #neurobiology
- #myelin
- #regeneration
- Myelination and remyelination depend on OPCs differentiating into mature oligodendrocytes.
- Myelination follows intrinsic developmental programs, while remyelination is triggered by injury.
- The microenvironment includes ECM and cellular components like neurons, microglia, and astrocytes.
- Microenvironmental dysregulation can cause aberrant myelination and remyelination failure.
- Pathological alterations occur in diseases such as MS, Alzheimer's, and ischemic stroke.
- Pro-remyelination strategies include BTK inhibitors and microglia replacement.