Research on vitamin D metabolic regulation in the pathogenesis of related diseases - PubMed
21 hours ago
- #Vitamin D Metabolism
- #Metabolic Regulation
- #Disease Pathogenesis
- Vitamin D is vital for calcium-phosphate balance, bone health, and immune regulation, metabolized through hepatic 25-hydroxylation and renal 1α-hydroxylation to active 1,25(OH)2D.
- 25(OH)D is the gold standard biomarker for vitamin D status; metabolism is regulated by PTH, FGF23, and VDR-mediated feedback, with CYP27B1 also expressed in extrarenal tissues.
- Dysregulated vitamin D metabolism links to diseases like VDDR-1A, CKD-MBD, TIO, granulomatous diseases, and CYP24A1 deficiency; 24,25(OH)2D may have biological functions and serve as a biomarker.
- Future research should standardize multi-parameter detection to advance vitamin D metabolomics in precision medicine for personalized diagnosis and therapy.