It's all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma - PubMed
8 days ago
- #RTK/Raf/MEK/ERK pathway
- #Glioblastoma
- #Therapeutic resistance
- The RTK/Ras/Raf/MEK/ERK signaling pathway is highly tumorigenic and linked to glioblastoma (GBM) aggressiveness.
- Therapeutic targeting of this pathway has faced challenges due to resistance mechanisms.
- Transcription factor dysregulation plays a critical role in acquired resistance to targeted therapies, radiation, and chemotherapy in GBM.
- Combining RTK/Ras/Raf/MEK/ERK inhibitors with transcription factor-targeted therapies is a promising approach to overcome resistance.
- Advancements in drug development and precision technologies offer potential for improving GBM treatment outcomes.