Balancing the efficacy and safety of chimeric antigen receptor T-cell therapy by affinity combination - PubMed
5 hours ago
- #affinity engineering
- #CAR-T therapy
- #therapeutic safety
- CAR binding affinity influences CAR-T-cell functionality and affects both efficacy and safety.
- Lower affinity CARs reduce side effects like cytokine release syndrome (CRS) but may compromise anti-tumor efficiency.
- High affinity CARs offer strong tumor control but can lead to exhaustion and increased cytokine production.
- Combining high- and low-affinity CARs in a product maintains strong functionality while reducing exhaustion and cytokine release.
- Low-affinity CAR-T cells demonstrate greater resilience to chronic antigen exposure over time.
- Affinity combination strategy improves the therapeutic index of CAR-T-cell products beyond single affinity engineering.