Photothermal reprogramming of synovial M1 macrophages reshapes the pro-inflammatory microenvironment to reverse temporomandibular joint osteoarthritis - PubMed
2 days ago
- #TMJOA
- #Photothermal therapy
- #Synovial macrophages
- Photothermal reprogramming of synovial M1 macrophages can reshape the pro-inflammatory microenvironment to reverse temporomandibular joint osteoarthritis (TMJOA).
- Targeted mild hyperthermia suppresses the NF-κB pathway in M1 macrophages, altering their secretome to reduce chondrocyte catabolism and enhance anabolism.
- Folic acid-conjugated Y8 nanocomposites (FA-Y8 NPs) were developed for precision M1-targeting photothermal therapy under 808 nm irradiation.
- FA-Y8 NPs successfully attenuated cartilage degradation in CFA-induced TMJOA mice by locally reprogramming synovial M1 macrophages.
- This study highlights thermal immunomodulation of synovial macrophages as a potential mechanism for TMJOA remission and introduces a targeted nanoplatform for joint inflammation control.