Nutritional Implications of Methotrexate in Osteoarthritis: A Systematic Review and Meta-Analysis - PubMed
5 hours ago
- #Osteoarthritis
- #Methotrexate
- #Nutritional Implications
- Methotrexate (MTX) may offer symptom relief in osteoarthritis (OA), reducing pain and stiffness.
- MTX showed significant pain reduction at 3 and 6 months in OA patients.
- No significant improvement in physical function was found in the primary analysis, but sensitivity analysis suggested a modest benefit.
- Adverse events were consistent with low-dose MTX use, and folate supplementation is recommended to mitigate nutritional risks.
- Larger, long-term trials incorporating nutritional parameters are needed to confirm MTX's role in OA treatment.