Targeting UHRF1 induces regression of aggressive mantle cell lymphoma - PubMed
5 hours ago
- #SOX11
- #Mantle Cell Lymphoma
- #UHRF1
- UHRF1 is significantly upregulated in mantle cell lymphoma (MCL) and linked to poorer survival rates.
- UHRF1 expression positively correlates with SOX11 and Ki-67 in clinical MCL samples.
- Knocking down UHRF1 induces apoptosis, G2/M-phase arrest, and suppresses MCL cell motility, invasion, and proliferation.
- UHRF1 silencing delays tumor growth in MCL xenograft models.
- Pharmacological targeting of UHRF1 with CM272 effectively inhibits MCL progression with a tolerable safety profile.
- SOX11 transcriptionally activates UHRF1 by binding to its promoter region.
- The SOX11-UHRF1 axis is crucial for tumor cell growth and proliferation in MCL.
- CM272 shows antitumor effects in preclinical MCL models with an acceptable safety profile.