Promotion of DFU Wound Healing via BRG1-COL16A1 Axis in Fibroblasts - PubMed
6 hours ago
- #Fibroblasts
- #Wound Healing
- #DFU
- Diabetic foot ulceration (DFU) is a major global health issue with high morbidity and recurrence rates.
- Current treatments like debridement and offloading have limited effectiveness, necessitating new molecular insights into wound repair.
- Multi-omics analyses identify fibroblast-derived COL16A1 as a key mediator in wound healing.
- COL16A1 enhances fibroblast activation and improves wound closure in diabetic mice.
- BRG1 is identified as the transcription factor that regulates COL16A1 expression by binding to its promoter.
- The BRG1-COL16A1 axis is proposed as a novel therapeutic target for chronic diabetic wounds.